Irf4 binding motif

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August undefined, 2024

WebDec 17, 2024 · BATF and IRF4 bind to AP-1-IRF-composite element (AICE) motifs 37, 38, 39, 40, but how BATF and other AP-1 transcription factors regulate IRF4 activity in the eTreg transcriptional program is... WebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is well-known that IRF4 controls numerous decision-making processes relating to B cell …

IRF4 as an Oncogenic Master Transcription Factor

WebMay 24, 2024 · NFKB1 is enriched in module “cyan” for binding motif, target transcripts as well as the corresponding pathway. In the same module, we noticed another TF, IRF4 (with its binding partner BATF), of which the binding motif and the corresponding pathway (IL-17 signaling) are both significantly enriched. WebDec 18, 2009 · Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo and furthermore revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. graphics card 2040

Transcriptional Regulation of Germinal Center B and

WebAug 25, 2024 · IRF4 is critical to full T cell activation, metabolic upregulation, and function but binds DNA weakly on its own and depends on interactions with other transcription … WebIRF4 IRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, which were first identified as being involved in the expression of interferon-induced genes. From: The Immune Response, 2006 Related terms: CD4 IRF8 T Cells Plasma Cell Lymphoma Germinal Center Cellular Differentiation Phenotype B Cell Proteome WebMay 23, 2013 · At higher concentrations, IRF4 binding shifted to interferon sequence response motifs; these enriched for genes involved in plasma cell differentiation. Our results support a model of “kinetic control” in which signaling-induced dynamics of IRF4 in activated B cells control their cell-fate outcomes. Graphical Abstract graphics card 2021 reddit

IRFs: master regulators of signalling by Toll-like receptors and ...

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WebOct 10, 2024 · To investigate whether PDGF D has any biological functions independent of its ability to activate β-PDGFR possibly via the CUB domain, three arginine residues in the R 340 R 341 GR 343 motif within the GFD, known to be critical for its binding to β-PDGFR, were mutated to alanines (TM). 26 To purify recombinant GFD-D proteins, the CUB domain ... WebMar 19, 2024 · In addition, we analyzed the distribution of DNA binding motifs within ±3 kilobase pairs (kb) from the sites bound by both IRF4 and NF-κB (Figure 2F; supplemental Table 4). As expected, both IRF and NF-κB binding motifs were enriched at the center of transcription factor binding sites. graphics card 2021 budgetWeb(a) Motif analysis of IRF4-binding sites based on the 1,338 most significant peaks (P < 10−10); the 100-bp sequences centered on the binding summit were used for analysis; … chiropractic omagh

"WebIRF4 is expressed at a lower level than IRF8 in these progenitor cells; however, IRF4 expression appears to be particularly important for the development of M2 macrophages. … " - Irf4 binding motif

Irf4 binding motif

Feed-forward regulatory loop driven by IRF4 and NF-κB in adult T …

WebMUM1 / IRF4 is a nuclear marker that is normally expressed in activated B and T cells, plasma cells and melanocytes. Involved in the differentiation of B cells and T cells. Marker … WebFeb 26, 2024 · Interferon regulatory factor 4 (IRF4) is a key transcription factor (TF) in the regulation of immune cells, including B and T cells. It acts by binding DNA as both a homodimer and, in conjunction with other TFs, as a heterodimer. The choice of homo and heterodimeric/ DNA interactions is a critical a …

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WebJan 20, 2024 · Abstract. Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) and key regulator of immune cell development and function. We report a recurrent … WebFeb 4, 2024 · IRF4 plays important roles in controlling the stimulatory properties of DCs but the mechanisms and contexts by which these are deployed to regulate Th responses are less well understood ( Bajaña et al., 2012; Vander Lugt et al., 2014 ).

WebApr 24, 2024 · The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to …

WebIRF4 binds to the canonical IFN-stimulated response elements (ISREs) as a homodimer, and it engages erythroblast transformation-specific IRF composite elements (EICEs) and activating protein 1... WebJun 21, 2013 · BATF leucine zipper motifs interact with interferon-regulatory factor 4 (IRF4) and IRF8 at AP-1–IRF consensus elements (AICEs). The discovery of the BATF–IRF …

WebJul 17, 2015 · The AICE motif directs assembly of IRF4 or IRF8 (601565) with BATF heterodimers and is also used in TH2, B, and dendritic cells. ... (164720) or Ap1 (165160) binding sites with Pu.1 (SPI1; 165170) or Batf (612476). At higher concentrations, Irf4 binding shifted to interferon sequence response elements, and these enriched for genes …

WebJan 7, 2003 · PU.1 is a hematopoiesis-specific ets family transcription factor expressed in myeloid and B cells (1, 2).PU.1 binds to DNA and recruits a transactivation partner, IFN regulatory factor 4 (IRF4) (), to an adjacent DNA sequence ().Phosphorylation of S148 in the PEST (proline, glutamine, serine, and threonine rich) domain of PU.1 is essential for strong … chiropractic oneWebApr 4, 2024 · IRF4 protects arteries against neointima formation by promoting the expression of KLF4 by directly binding to its promoter. We propose that the Irf4 locus functions as the "reader" of TCR signal strength, and in turn, concentration-dependent activity of Irf4 "writes" T helper fate choice. graphics card 2022WebIRF-4 was initially characterized in lymphocytes and was shown to function as both a transcriptional repressor and activator. More recently, IRF-4 expression and function have … chiropractic occupational therapyWebApr 24, 2024 · The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to … chiropractic olympic commercialWebTo optimize motif analysis to distinguish sequence requirements of high-affinity versus a low-affinity AICEs, we needed to identify which motif(s) within a peak were functional for BATF/IRF4... graphics card 2021WebApr 24, 2024 · Such diverse functions of IRF4 are thought to rely on multiple DNA binding motifs to which IRF4 binds as heterodimers or its homodimer depending on its protein level. 15 IRF4 binds the Ets-IRF composite elements (EICEs) with PU.1, 16 the AP-1-IRF composite elements (AICEs) with AP-1 family such as Batf, 17, 18, 19, 20 and the interferon sequence … chiropractic one liverpoolWebSep 1, 2006 · The mammalian IRF family comprises nine members: IRF1, IRF2, IRF3, IRF4 (also known as LSIRF, PIP or ICSAT), IRF5, IRF6, IRF7, IRF8 (also known as ICSBP) and IRF9 (also known as ISGF3γ) 4, 5.... graphics card 2070